Scientists from more than 30 research institutions including Beijing Tongren Hospital, Capital Medical University, Singapore National Eye Center and Singapore Genomics Research Institute have discovered 3 new susceptibility genes for primary angle-closure glaucoma (PACG) through genome-wide association analysis Location, is expected to provide help for early screening of patients. Professor Wang Ningli of Beijing Tongren Hospital of Capital Medical University and Professor Ontin of National Eye Centre of Singapore as co-corresponding authors recently published this new achievement online in the internationally renowned academic journal Nature? Genetics.
PACG has 15 million patients worldwide, 80% of whom live in Asia. According to Wang Ningli, primary glaucoma is mainly divided into angle type and angle-closure type. PACG has a high incidence in Chinese and Asian populations. Without active treatment, about 2/3 of them can eventually cause blindness. It can be said that PACG is the leading cause of blindness in China.
According to anatomical research, about 10% of people over the age of 40 in China are susceptible to PACG, and about 10% of them will eventually get sick. Therefore, it is a research hotspot in this field to screen out the final onset patients early and carry out early intervention treatment. The discovery of three new PACG susceptibility loci indicates that genetic factors play a role in the formation of PACG. This is a landmark discovery.
This study is an international multi-center study of cross-region, cross-ethnicity, and cross-disciplinary. A total of 3761 patients and 18551 healthy controls from 10 countries and regions were collected. learn. The three PACG susceptibility loci found in the study were PLEKHA7, COL11A1, and rs1015213. The above three susceptibility genes may affect the development and regulation of trabecular meshwork, iris, ciliary body, etc. and eventually cause PACG. At the same time, they may also be related to hyperopia and small eyeballs.
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