Systemic lupus erythematosus (SLE) is an autoimmune-mediated lethal autoimmune disease involving multiple systems. For many years, due to the constraints of complex pathological mechanisms, lack of therapeutic targets, and long periods of animal models of related diseases, the research progress of SLE therapeutic drugs has been slow.
The research team of Zuo Jianping, a researcher at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, has devoted himself to the research of SLE therapeutic drugs for many years and has achieved certain research results. The water-soluble artemisinin derivative SM934 is a new candidate drug for the treatment of SLE. The research results obtained in the experiment of lupus disease animal model (MRL / lpr strain female mice) have been published in Arthritis & Rheumatism, and the therapeutic effect and mechanism of SM934 are described. .
As a series of research work, the research group Dr. Hou Lifei and He Shijun and others recently proved that SM934 has good efficacy and novel in experimental treatment of another classic spontaneous SLE disease animal model (NZB × NZW F1 strain female mice). Immune regulation mechanism. The results show that oral administration of SM934 can significantly improve the symptoms and disease progression of SLE in NZB × NZW F1 mice, reduce the incidence of fatal lupus nephritis, and significantly prolong the life cycle of mice.
Further mechanistic studies have shown that SM934 can induce activated pathological T cells into apoptosis, increase the proportion of regulatory T cells, and promote the innate immune cells to secrete the immunosuppressive cytokine IL-10. Recent studies have shown that IL-10 is still an immunosuppressive regulatory cytokine in the course of SLE disease, but its inhibitory effect will depend on the responsiveness of responding cells. If you can use drug intervention and other means to selectively clear the activated pathogenic T cells and promote the renewal of T cells, the immunosuppressive effect of IL-10 will be reflected and enhanced, so that the immune system will return to a steady state.
Related research papers were published online in PLoS ONE in March 2012. The project was supported by research funds from the Chinese Academy of Sciences, Shanghai Science and Technology Commission, and the National Eleventh Five-Year Plan.
The water-soluble artemisinin derivative SM934 has a good effect in the experimental treatment of female mice of the NZB × NZW F1 strain
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