A breakthrough in the synthesis of biodegradable polyester by genetic engineering

Under the support of the National Natural Science Foundation of China, Tsinghua University’s Chen Guoqiang and his collaborators have successfully developed a new method for the synthesis of biodegradable polyesters in the world by conducting cross-sectional studies in the fields of polymer science, chemical engineering, and microbiology. A new type of biodegradable polyester 3-hydroxybutyric acid and 3-hydroxyhexanoic acid copolymer (P HBHHx) with excellent performance. The result won 1 first prize of Beijing Science and Technology Progress Award in 2001 and the second prize of National Technological Invention in 2002. 1 item.
At present, macromolecular synthetic materials are basically made of fossil resources such as petroleum. Chen Guoqiang's team established a new technology for the synthesis of genes. Four new genes related to the synthesis of PHA (polyhydroxyalkanoate) were discovered and stored in an international gene bank. Three new genes associated with synthetic PHA were cloned. gene. Using these new genes and mutants to construct a highly effective microbial expression system for the synthesis of novel performance PHA, an ongoing expansion experiment of PHA preparation; a new type of P HBHHx synthesis using the strains obtained by screening, in the "Ninth Five-Year Plan" research project Supported in the world to achieve the first industrial production of P HBHHx, products exported to the United States, has earned more than 1 million US dollars for the country; published nearly 20 high-level papers, applied for 3 Chinese patents, and obtained 1 granted Chinese patent. These achievements have made China's research in this field an international leader.

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