May 9, 2014 / Bio Valley BIOON / -- AstraZeneca announced on May 8 that it started the phase III project of immunotherapy MEDI4736. MEDI4736 is a monoclonal antibody that targets programmed cell death ligand 1 (PD-L1) and is currently being developed for the treatment of non-small cell lung cancer (NSCLC) and other cancers. The first study of stage III NSCLC, PACIFIC, will be conducted in patients with locally advanced, unresectable (stage III) non-small cell lung cancer (NSCLC) who have completed chemoradiotherapy and have no evidence of tumor progression, and will investigate MEDI4736 versus consolation. The improvement in disease progression-free survival (PFS) and overall survival (OS). The PACIFIC trial is the first key study of MEDI 4736 in this patient population.
MEDI4736 is a fully humanized monoclonal antibody that targets programmed cell death ligand 1 (PD-L1). The signal from PD-L1 helps the tumor evade the examination of the immune system. MEDI4376 is able to block these signals against the immune evasion tactics of the tumor. Currently, AstraZeneca is developing MEDI 4736 and other immunotherapeutics (IMTS) to enhance the patient's immune system to attack cancer cells.
The PACIFIC trial is expected to recruit 702 patients at more than 100 outlets worldwide.
MedImmune, a biologics research and development division of AstraZeneca, is currently building a comprehensive immuno-oncology program, including MEDI4736, tremelimumab, MEDI0680 and MEDI6469. Monotherapy and combination therapies are also being explored in a range of tumor types.
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