Preparation method and pharmacological effect of lysergic acid diacetamide

Preparation method and pharmacological effect of lysergic acid diacetamide

Lysergic acid diethylamide (Lysergic acid diethylamide, or LSD, often referred to as acid in colloquial language) is a representative of hallucinogens. It is a derivative of lysergic acid and a chemical component of natural ergot alkaloids. Ergot is extracted from a natural crop fungus such as ergot, which can survive in certain grains such as rye and wheat.

In 1935, Swiss biochemists extracted lysergic acid from ergot bacteria and mixed it with another substance, ammonium diacetate, to obtain LSD. This was in 1943, but its pseudo-psychotic effect was not found at the time. When a chemist Albert Hofmann studied the central stimulating performance, he personally experienced an unusual mental effect, which is similar to the performance of mental illness, and made a specific description. Later, some people conducted a systematic study on it in the psychiatric clinic, and also confirmed the active effect of this drug, and speculated that this effect is exogenous.

Pharmacological effects

LSD is considered to be the most amazing and strongest psychedelic drug in the contemporary era, in which a very small amount of LSD-25 (about 20-25 micrograms) is enough to produce hallucinations. Drug users usually take a dose of 50-300 micrograms. The 1960s were the era of the LSD explosion, which was all the rage in the United States. At present, the popular LSD psychedelic agents are made into colorless and odorless powders, tablets, capsules, and solutions. The method of use is generally oral, or sprinkled on tobacco for inhalation, or injected intravenously or subcutaneously. It is worth mentioning that in the foreign market, there is a colorful cartoon that is particularly suitable for children to play and can be used for stamp collection. These cards are about the size of a pencil, and the patterns on it are very attractive, such as Superman and Denis characters. , Brave sipson, butterfly, etc., so its appearance is very popular among elementary school students. In fact, this is a small piece of paper impregnated with LSD. They are known as "bluestar". The processed LSD is mainly absorbed through the skin, and the skin absorbs very quickly when it comes into contact with this kind of card, which makes people unconsciously take drugs. If it is touched frequently, it can cause coma and death. China should be highly vigilant about its appearance.

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